Various organic anion species have important biological functions in organs. Particularly metabolites of catecholamine, such as homovanillic acid and vanillylmandelic acid, can be utilized as disease markers for neuroblastoma.(1) The instrumental detection after chromatographic separation is generally used to analyze organic anions. However, instrumental analysis demands special skills of analysts. Hence simple detection methods for anions are desired in medical and pharmaceutical fields.To develop novel detection method with no separation operation, gold nanoparticles covered with receptor molecules for anion species were synthesized. These nanoparticles adsorb sulfate ion in aqueous solution, and show its fluorescence change under the concentration range of sulfate ion from 10-4 M to 10-3 M.(2) This selectivity is probably controlled by selecting receptor molecules on the surface of gold nanoparticles. In our research, bis[2-(3-(substituted)thioureido)ethyl]disulfide is adopted for that purpose and its selectivity for anion species is measured in bulk acetonitrile solution. This is required for the development of this novel detection method to reveal the relation between the selectivity of receptor molecules on gold nanoparticles and the selectivity in bulk solutions.(1) Strenger, V.; Kerbl, R.; Dornbusch, H. J.; Ladenstein, R.; Ambros, P. F.; Ambros, I. M.; Urban, C. Pediatr. Blood Cancer 2007 , 48, 504-509.(2) Tomita, K.; Ishioka, T.; Harata, A. Anal. Sci. 2012 , 28, 1139-1144.

Development of the detection method for organic anion species utilizing gold nanoparticles

246th National Meeting (2013)

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