Metallic nanosturctures are known to dramatically modify the fluorescence of adjacent fluorophores. Here we directly compare the fluorescence enhancement of different dyes by metal nanoshells, where SiO2 serves as both a holder of the dye and a spacer layer between the Metal nanoshell and the dye. The structure and composition of dye-doped SiO2 core/silver shell nanostructures were characterized by UV-visible spectroscopy, particle size analyzer (PSA), transmission electron microscopy (TEM)  and fluorescence spectroscopy. The dye-doped SiO2 nanoparticles whose diameters are around 50 nm were formed by  water-in-oil (W/O) microemulsion method. The dependence of fluorescence intensity on the shape of metal nanoshell coating which caused by different silver coating methods was investigated. With metal nanoshell, we demonstrate the enhancement factor (EF) changed from 0.1 to 2. This change in fluorescence shows potential for contrast enhancement in fluorescence-based imaging for clinical diagnosis and monitoring processes in biological systems.

Synthesis and fluorescent property characterization of dye-doped SiO<sub>2</sub> core/silver shell nanostructures

246th National Meeting (2013)

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Synthesis and fluorescent property characterization of dye-doped SiO2 core/silver shell nanostructures

Synthesis and fluorescent property characterization of dye-doped SiO₂ core/silver shell nanostructures