This paper explores the technology of computer-assisted synthesis planning, its beginning, evolution, and impact.  Once chemists could communicate in their natural language (structural diagrams) and the computer could carry out the symbolic algebra of chemical reactions we entered a new era for organic chemists and chemical information processing.  Chemists had a new co-worker, one that would work faster, smarter, and cheaper each year.Fast forward 44 years, has the new partnership achieved all it was capable of?  What can we expect for the future?

Synthesis planning: Something about reactions, representation, relationships, and reasoning

246th National Meeting (2013)

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