Synthetic multivalent glyco systems have great importance due to their potential in several biological interactions. Self-assembly mediated by noncovalent interactions is an effective approach to construct synthetic multivalent glyco materials. This energy efficient technique provides stability and solubility in aqueous solution and displays discrete morphologies. By combined help of the noncovalent interactions, self-assembling peptide amphiphile molecules can form high-aspect-ratio nanofibers. Side chains on the peptide skeleton provide multivalency, which is an interesting platform to explore several receptor-ligand interactions. In this study, multivalent glyconanostructures emulating glycosaminoglycan functions was produced. The glycosaminoglycan mimetic self-assembled nanofibers are exploited as a scaffold to perform in vitro chondrogenic differentiation of mouse chondroprogenitor ATDC5 and mouse mesenchymal stem cells.

Supramolecular glycopeptide nanosystems and their effect on the chondrogenic differentiation

246th National Meeting (2013)

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