In Nature, it is well known that the activity of metalloproteins is dictated by the chemical environment at the active site. As several studies have shown, the hydrogen bonding present in the proteins' secondary coordination sphere mediates the stability of intermediates at the active site. Using Nature for inspiration, we have designed metal complexes with ligand scaffolds ideally suited for the activation and stabilization of small molecules. The ligand scaffolds feature a secondary coordination sphere for hydrogen bonding capable of binding substrate selectively and stabilizing reactive intermediates on first-row transition metals.

Utilizing a modular ligand design featuring a secondary-coordination sphere to mediate multielectron transformations

246th National Meeting (2013)

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