Flowing solutions of organic substrates and stoichiometric reagents through beds of heterogeneous catalysts can greatly streamline processes if the stoichiometric reagents have no byproducts or only volatile or innocuous byproducts.  The product streams can be directly flowed into the next synthetic step or concentrated to the product without added work up steps.  In the catalyst bed, the catalyst surface area is extremely high, and pressures and temperatures can be very high, promoting fast reactions by the brief, controlled exposure to these powerful reaction conditions.  Rapid chemistry provides high throughput from small reactor volumes and short startup and shutdown times.  Here we describe flow hydrogenations and flow oxidations (including aerobic oxidations) using heterogeneous catalysts for the preparation of pharmaceutical intermediates.  In addition to streamlining processes, these reactions provide increased reactivity and/or selectivity relative to their batch reaction counterparts.

Flow oxidations and reductions using heterogeneous catalysts

246th National Meeting (2013)

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