Systems Pharmacology is an emerging subject of study, which aims to take into account of complex relationships among diseases, drugs, genes, and phenotypic observations to help develop future drugs with maximal intended efficacy and minimal side effect profiles. In this work, we show that a new systems pharmacology approach�by incorporation of drug structures, drug targets, drug target ontological information, and drug target network information�can significantly boost the accuracy of adverse drug response (ADR) predictions. The approach has new implications for future drug screening and drug evaluation practices during the pre-clinical development phase.

New systems pharmacology approach toward better adverse drug response predictions

246th National Meeting (2013)

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