A naturally occurring thyroid hormone metabolite, 3-Iodothyronamine (T1AM), is a fast acting derivative which activates the Trace Amine Associated Receptor (TAAR1). In mice, T1AM exhibits effects opposite of those induced by the thyroid hormone. This presents a novel regulatory mechanism of thyroid hormone action. Studying this regulatory mechanism may lead to a greater understanding of thyroid hormone biology and may have medicinal value. The project described herein examines T1AM analogs that contain a urea linker between the aryl groups. The structure activity relationship of these analogs is further explored by examining many functional groups and different connections around the phenethyl amine group. These analogs will be used in a cell-based assay to examine TAAR1 regulation.

Progress towards the development of urea based modulators of the trace amine associated receptor

246th National Meeting (2013)

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