In this study we have prepared 19F containing polymer nanoparticles from linear or star-shaped amphiphilic block copolymers incorporating chemotherapeutics for the treatment of breast cancer.The polymer nanoparticle carriers were extensively studied in respect to their toxicity by several in vitro techniques and in several cell lines, and was found to be non-toxic and induced no apoptosis. Efficient drug delivery of doxorubicin, with nuclear localization, as well as phantom imaging by 19F-MRI was demonstrated. Tailoring of the hydrophobic core from linear to star shaped polymers as well as the copolymer arm composition was shown to affect both drug release kinetics and phantom imaging quality. By utilizing diffusion NMR, taking advantage of the 19F signal we could study the interaction and size changes of the polymer nanoparticles in complex media with serum or whole plasma. This represents a new application of diffusion NMR for studying the plasma protein corona of nanoparticles with broad implications in nanomedicine and nanotoxicology.Figure 1. Effects of media composition on T1 and T2 relaxation.

Non-protein binding theranostic agents for breast cancer treatment

246th National Meeting (2013)

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