Fibrinogen is a multiprotein complex which, when activated, aggregates to form firbin, a net-shaped molecular formation which is fundamental for the coagulation of blood following a wound or when an extraneous body comes into contact with blood (i.e., graft implants).Thus, adsorption of fibrinogen on material surfaces play an important role in viability of those materials for implants. It is known that fibrinogen is very flexible in solution, a fact that made it hard to crystallize. The flexibility of fibrinogen can also be observed in adsorption studies. Here we examine the flexibility of fibrinogen using atomistic molecular dynamics simulations. Simulations of fibrinogen in solution are used as a reference to evaluate the behavior of fibrinogen on material surfaces and study the initial adsorption stages . This in turn may have implications for medical applications such as material design for implants.

Fibrinogen flexibility and implication for adsorption

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.