Various 5-substituted tetrazoles were synthesized from aryl and alkyl nitriles and sodium azide. The tetrazoles were recovered in high yield under mild conditions when the reaction was catalyzed by Yb(OTf)3 utilizing DMF or water as a solvent. Other rare earth metal catalysts were also studied.

Synthesis of 5-substituted 1H-tetrazoles catalyzed by ytterbium triflate hydrate

246th National Meeting (2013)

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