A novel method for the efficient construction of highly substituted benzene rings has been developed. This reaction sequence involves the three component synthesis of pyrrole derivatives through the coupling of Fisher carbene derivatives with enyne imines followed by Diels-Alder reaction with activated alkyne dienophiles. In many cases this process can be accomplished as a one-pot reaction, depending on the reactivity of the dienophile. The scope and limit of this process will be discussed.

Novel multiring synthesis of highly substituted benzene rings

246th National Meeting (2013)

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