We are studying the reactions of various amino acids with analogs of the anticancer drug cisplatin that differ in both size and shape.  Reaction of the drug with proteins likely precedes reaction with DNA in the body, and both size and shape of the platinum complexes often affect the reactions with protein targets more than with DNA targets.  In this study, platinum (II) oxalate complexes are being reacted with the amino acids histidine and cysteine at various pHs, and reactions are being monitored by proton NMR spectroscopy.  We hypothesize that calculated rate constants for histidine will not change as the carrier ligand of the analog is changed and bulk is increased, but we expect decreased rates for cysteine as bulk is increased.  Thus, sufficient bulk may increase the number of histidine adducts compared with cysteine adducts.

Reaction rates of amino acids with analogs of the anticancer drug cisplatin

246th National Meeting (2013)

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