Generator-produced 62Cu (9.7-minute half-life) offers the benefits of a very short-lived radionuclide for positron emission tomography (PET) without requiring a nearby cyclotron. We have evaluated the performance of a commercial 62Zn/62Cu microgenerator system (Proportional Technologies, Inc.), and a kit-based radiopharmaceutical synthesis method, for production of 62Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)) for PET perfusion imaging. The microgenerator delivers 62Cu2+ in 0.25-mL 0.2M-HCl:1.8M-NaCl from an anion exchange resin that selectively retains the 62Zn(II). The centrally manufactured generator, calibrated to contain ~50-mCi 62Zn on the morning of arrival at the clinical site, can repeatedly provide 62Cu at 30-40-minute intervals for radiopharmaceutical labeling throughout a clinical day. The 62Cu-ETS radiopharmaceutical was obtained in an injectable isotonic solution (4-mL) by eluting the 62Cu2+ directly into a reconstituted lyophilized vial containing the H2ETS ligand, NaOAc, and excipients. Elapsed time, from generator elution to patient injection, was consistently under 5-minutes. Using 37 generators, a total of 45 doses of 62Cu-ETS have been delivered for tumor perfusion imaging with whole-body PET/CT. Generator elution yield averaged 90%, with extremely low 62Zn-breakthrough (<0.001%). Patient doses of 62Cu-ETS averaged 18.2 � 4.6 mCi (670 � 170 MBq), or approximately 70% of the total 62Cu activity at the time-of-elution. The 62Zn/62Cu microgenerator has proven a reliable source of 62Cu under the conditions of clinical use. Additionally, the kit-based synthesis method has been rapid, robust and convenient for �on-demand� delivery of 62Cu-ETS for PET/CT. ?

Performance of a 62Zn/62Cu parent/daughter generator system, and a kit-based radiopharmaceutical synthesis method, for PET imaging with 62Cu

246th National Meeting (2013)

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