Metabolomics, the process of measuring metabolite concentration changes in biofluids such as urine, serum/plasma, sweat, or saliva or that of intact cells, tissues, or single-celled organisms, is the missing piece of the omics puzzle (genomics, transcriptomics, proteomics) necessary for providing a holistic view (DNA, RNA, protein and metabolites) of the response to drug exposure. The combination of mass spectrometry-based metabolomics, chemometrics, and the strategic use of genetically modified mice provides an attractive raft of technologies with which to examine mechanisms associated with drug-induced liver injury. Recent studies using the model hepatotoxicant acetaminophen will be presented.

Mass spectrometry-based metabolomics to understand drug-induced liver injury

246th National Meeting (2013)

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