We present an injectable and degradable PEG/collagen hydrogel system with robust networks for use as elastomeric tissue scaffolds. Poly(ethylene glycol) (PEG) and PEG-co-lactic acid were covalently cross-linked and collagen was physically cross-linked to form a semi-interpenetrating hydrogel network. The mechanical strength of the hydrogels depends predominantly on the PEG concentration but the incorporation of collagen into the PEG network enhances hydrogel viscoelasticity, elongation, and also cell adhesion properties. Experimental data show that this hydrogel system exhibits tunable mechanical properties. The hydrogels allow cell adhesion and proliferation in vitro. The results support the prospect of a robust and semi-interpenetrating biomaterial for elastomeric tissue scaffolds applications. 

Robust and degradable hydrogels from poly(ethylene glycol) and collagen interpenetrating networks

246th National Meeting (2013)

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