The controlled delivery of actives is important in a variety of applications including the administration of pharmaceuticals, pesticides and antimicrobials.  Dendrimers and hyperbranched polymers are particularly suited for controlled delivery because they are polymeric materials with molecular architectures providing the highest branching density of any polymeric material as well as the highest end group density.  One potential delivery mechanism for biobased hyperbranched polyesters is the release of the active as the polymer biodegrades.            A series of hyperbranched polyesters based on glycerol, adipic and succinic acid were synthesized.  The molecular weight of these polyesters was targeted using bimolecular nonlinear polymerization methodology which uses the stoichiometry of reactive functionality to control the molecular weight of the resulting hyperbranched polyester.  The polyesterification reaction was characterized using both 1H and 13C NMR spectroscopy.  Actives were bound to the hyperbranched polyesters and their time-release characteristics defined.

Characterization of hyperbranched polyesters using NMR spectroscopy

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.