There is huge potential to improve patient treatment by obtaining physiological measurements of important analytes (i.e., PO2, PCO2, pH, glucose, etc.) in real-time data using implantable sensors. Although miniaturized sensors have existed for several decades, most of this technology never becomes widely used due to unreliable analytical data from implanted sensors caused by the biological response from the body. A possible option to overcome this complication with blood contacting devices is through the utilization of nitric oxide (NO). NO is a free radical gas that is produced in our body that has a variety of important functions. A specific example demonstrating the importance of NO is seen in endothelial cells that line our vasculature where NO is produced continuously at an estimated flux of 1- 4 x 10-10 mol cm-2 min-1, which prevents platelets from becoming activated and maintains vascular tone. The objective of this research is to develop a high capacity, controlled NO releasing material by covalently linking hyperbranched polyamidoamine molecules to the backbone of poly (vinyl chloride) (PVC) to create a dendronized polymer with high functionality. The structure is then further modified to release NO through homolytic cleavage using light by covalently linking S-nitroso-N-acetylpenicillamine (SNAP) to the primary amine sites. An example of the final derivatized polymer is shown in figure 1. We present the synthesis, characterization and NO release properties of this modified NO-releasing PVC material.

Controlled nitric oxide releasing dendronized poly(vinyl) chloride for improving biocompatibility of implantable devices

246th National Meeting (2013)

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