Hydrogels are expected to be the most excellent scaffolds in the field of biomedical engineering such as protein, nucleotides, and cell delivery system. A hydrophilic environment provided by the hydrogels has an excellent condition for cell viability and proteins without denaturation. Especially, porous hydrogels have been widely used in a large field of medical engineering, such as cell-based therapies or drug delivery systems.Herein, a porous hydrogel was formed with PVP coated iron oxide nanoparticles and acrylamide and N,N-methylenediacrylamide monomers in ammonium persulfate and N,N,N',N'-tetramethylethylenediamine initiating system. The gelation was achieved by cryogel method under the freezing condition, around -20 oC. In freeze-and-thaw process, the iron oxide nanoparticles were homogenously entrapped in the porous hydrogel matrix known as macroporous ferrogel. By Scanning Electron Microscope Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/9585_herbig_series.jpg' alt='' />, the average size of the pore in ferrogel was measured around 200 micrometers, which indicated a macroporous structure. A physical property of the hydrogel altered with an encapsulation of iron oxide nanoparticles and at 4 wt% monomer concentrated solution, the proper gelation was formed. The ferrogel was shrunk and expanded under the magnetic field pulse and the extents of shrinkage and expansion was strongly dependent on the magnetic forces. This porous ferrogel can be a potential candidate for applying to regeneration of stem cell differentiation toward specific cell lines with magnetic stimulations.

Magnetic field-reactive macroporous ferrogels

246th National Meeting (2013)

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