Sequence control offers the potential to tune polymer properties while exploiting the unique properties of specific monomers.1 Poly(lactic-co-glycolic acid) (PLGA) is a polymer that is valued for originating from biorenewable resources and for exhibiting hydrolytic degradation to give biodegradable products. The ability to tune the properties of PLGAs has, until recently, been limited to control of molecular weight and the adjustment of the glycolic to lactic acid ratio. Using segmer assembly polymerization, a variety of sequenced PLGAs have been prepared.2 Sequence fidelity is demonstrated by examination of the MALDI-MS data and sequence specific bulk behavior by characterization of the thermal and mechanical properties of the polymers. Sequence specific hydrolysis behaviors can be seen in both the degradation profile3and the penetration of water into the bulk. (1) Badi, N.; Lutz, J.-F. Chem. Soc. Rev. 2009  , 38, 3383. (2) Stayshich, R. M.; Meyer, T. Y. J. Am. Chem. Soc. 2010  , 132, 10920. (3) Li, J.; Stayshich, R. M.; Meyer, T. Y. J. Am. Chem. Soc. 2011  , 133, 6910.

Sequenced poly(lactic-co-glycolic acid) copolymers

246th National Meeting (2013)

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