Some of the unique advantages of the use of electrostatic assembly methods to generate drug release systems include the ability to introduce unusually high loadings of biologic drugs, and the ability to incorporate multiple drugs that can be released with exquisite control to achieve unique co- and sequential release profiles from surfaces.    New methods of achieving controlled and highly effective mediation of wound healing will be addressed, including the unique release of siRNA and growth factors into chronic wounds, and the use of these systems for the healing of large bone segmental defects as well as the integration of bone on biomedical implants.   Finally, new approaches to the release of DNA, antigen, and adjuvants into the skin dermis layer from the surfaces of microneedles demonstrates that the gradual and controlled release of small amounts of DNA can lead significantly enhanced immune responses for vaccine delivery which can significantly outperform other forms of DNA vaccines such as electroporation and intradermal injection.    In these examples, the effect of rate of release and the nature of delivery from these unique platforms will be discussed. 

Electrostatic assembly for tuning biological-materials interfaces

246th National Meeting (2013)

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