A shortage of available organ donors has created a need for engineered tissues. Through combinations of scaffolds, biochemical factors and cells, engineered constructs resembling natural tissue are created. Polymer-based hydrogels that break down inside the body are often employed as scaffold materials, and many different click chemistries have been utilized for this purpose.  In this presentation, gels formed by oxime and hydrazone chemistries will be discussed.  Both are highly efficient reactions, and the latter is readily reversible.  The reversibility of hydrazone bonds allows the gel to reform when the bonds are cut and then brought together (i.e. to self heal).  The synthesis of poly(ethylene glycol) based systems, formation of gels, mechanical properties, and kinetics will be discussed.  Incorporation of cell binding factors and enzyme cleavable cross-linkers, and viability of mesenchymal stem cells within the hydrogels will be presented. 

Biocompatible hydrogel by oxime and hydrazone click chemistries

246th National Meeting (2013)

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