 Unprecedented advances in controlled radical polymerization (CRP) techniques and facile �click� conjugation chemistry now allow synthetic tailoring of precise, nano-scale architectures appropriate for drug/gene delivery. Reversible addition-fragmentation chain transfer (RAFT) polymerization and its aqueous counterpart (aRAFT) afford quantitative control over key synthetic parameters including block length, microstructure, and placement of structo-pendent and structo-terminal functionality for conjugation of active agents and targeting moieties. Amphiphilic (co)polymers synthesized by RAFT appear to be especially attractive for applications ranging from in vitrodelivery of therapeutics to environmental remediation. In many cases, polymerization, conjugation, loading (capture) and stimulus-induced release can be accomplished directly in aqueous media. This presentation will focus on synthetic strategies utilizing RAFT and facile side- and end-chain reaction chemistries to afford a) modular delivery architectures to aid in stabilization, trafficking and stimulus-induced release of �packaged� therapeutic small interfering RNA (siRNA) and b) unimeric micelles or �polysoaps� for oil spill remediation.

Functional RAFT and aRAFT copolymers: Synthetic architectures for targeted gene delivery/environmental remediation

246th National Meeting (2013)

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