In this study we describe the evaluation of a recently developed supercritical fluid chromatography (SFC) instrument for automated chiral SFC method development. The greatly improved gradient dwell volume and liquid flow control of the new instrument in combination with the use of shorter columns containing smaller stationary phase particles affords chiral SFC method development that is faster and more universal than previous systems. By using this instrument, we develop new methods to isolate and identify complex isomeric species.

Improved chiral SFC screening for analytical method development

246th National Meeting (2013)

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