The discovery of new antiviral nucleoside analogues is hampered by a lack of heterocyclic scaffolds that imitate purine and pyrimidine bases.  An appropriately substituted 1,2,3-triazole ring should be able to serve in place of a purine ring system.  A number of new triazole-based nucleoside analogues have been prepared.  Each has a sugar or sugar analogue off N1 of the triazole ring with a group off C4 that can engage in Watson-Crick base pairing.  Synthetic procedures and preliminary screening results will be presented.

Antiviral 1-glycosyl-1,2,3-triazoles

246th National Meeting (2013)

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