Amyloid-� (A�) and tau-neurofibrillary tangles are the proposed pathological markers of Alzheimer's disease (AD). With the goal of early diagnosis of AD, and differentiation from other clinically overlapping neurodegenerative disorders, this project aims to further understand amyloid pathology in AD by using PET imaging to evaluate the role of metal ions known to accumulate in high quantities in A� plaques. Carbon-11 labeled radiopharmaceuticals based upon N',N'-dimethyl-N4-(pyridin-2-ylmethyl)benzene-1,4-diamine, a scaffold recently demonstrated to bind A� plaques and sequester metal ions, have been synthesized. This presentation will report chemical and radiochemical syntheses, quality control testing, and preliminary evaluation of proof-of-concept in vivo using rodent and primate microPET imaging experiments, and in vitro using autoradiography experiments with post-mortem brain samples from AD patients.

Synthesis and evaluation of PET probe targeting metal-A� aggregates

246th National Meeting (2013)

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