A series of curcumin analogues has evolved within the last decade, leading to the attention of synthesizing and SAR (structure activity relationship) modification on favored regions a key component on the natural compound.  Curcumin isolated in rhizomes from the plant curcuma longa, has shown to be a dietary supplement and often as food coloring due to its yellow pigment.  Curcumin analogues with modifications on the phenyl rings and beta-diketone region have shown to be potential anti-prostate cancer agents on androgen receptors.  We designed and synthesized over 20 new analogues classified into 3 series: heterocyclic analogues, hydrophobic analogues, and hydrophilic analogues all having varying substituents in the different regions.  These newly synthesized compounds were tested for cell viability on prostate cancer cells and molecular docking studies were performed to confirm the binding site of the androgen receptor.  This study was designed not only to establish novel synthesize curcumin analogue for anti-tumor activity but also to provide evidence that these newly synthesized analogues may be implemented in the treatment of other types of cancer because of its scaffold modification.

Design and synthesis of novel curcumin analogs for antiprostate cancer

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.