In cancer chemotherapy, metal-based complexes have been recognized as the most promising means of inhibiting cancer growth due to the successful application of cis-platin and its derivatives above many of the existing organic anticancer agents. However, one of the greatest challenges that are preventing rational drug design of metal-based anticancer complexes is complexity of the mechanism of their operations due to lack of proper knowledge of their targets. In this study, some ruthenium(II) complexes have been synthesized and characterized by elemental analysis and spectroscopic studies. Computational docking methods were used to predict their most probable targets and the mechanism of their activities. The interesting features of the binding of the complexes showed that some of the complexes preferentially target specific macromolecule than the other which is an indication of their specificity and possibility of their therapeutic combination without severe side effect that may come from competition for the same target. Both experimental and theoretical results were compared. It was found that introduction of some unusual ligands significantly improve the activities of most of the complexes studied

Design, synthesis, and biological studies of Ru(II) complexes of some nitrogen chelating ligands

246th National Meeting (2013)

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