The development of a single-step biomimetic Fe(III)-promoted coupling of vindoline with catharanthine and subsequent in situ oxidation to provide vinblastine, its extension to the total synthesis of related natural products and key analogs, the generalization and scope of the synthetic methodology, and mechanistic insights into the reactions will be presented. Key studies addressing the structural features of vinblastine contributing to its tubulin binding and antitumor properties will be discussed.

Innovative methodology discovered in the total synthesis and diversification of vinblastine

246th National Meeting (2013)

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