An Aedes aegypti larval toxicity bioassay was performed on compounds representing many classes of natural compounds including polyacetylenes, phytosterols, thiophenes, flavonoids, sesquiterpenoids, and triterpenoids. Among the compounds studied, two eudesmanolides, alantolactone and isoalantolactone, as well as many thiophenes showed larvicidal activities against Ae. aegypti and therefore were chosen for further structure-activity relationship investigations. Structural modifications were performed on both alantolactone and isoalantolactone in an effort to understand the functional groups necessary for maintaining and/or increasing its activity and to possibly lead to more effective insect control agents. Structure-activity evaluations of thiophenes found relationships between the number of thiophenes rings and acetoxy groups.

Natural product-based insecticidal structure activity relationship investigations

246th National Meeting (2013)

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