?The Lilly Open Innovation Drug Discovery program (OIDD) was established to provide a platform for the engagement of investigators worldwide in the submission of novel compounds for therapeutic potential evaluation.  OIDD has been embraced by the scientific community, both scientists and technology transfer professionals alike.  To date, more than 300 academic institutions and small biotech companies in over 30 countries have become affiliated with the program.  Thousands of compound samples have been evaluated in the phenotypic and target-based disease modules included in the OIDD screening panel, providing important scientific value to small companies and resource-constrained faculty. In 2011, Lilly evaluated a collection of compounds submitted to OIDD by the University of Valencia. From this collection, three compounds with good drug-like properties displayed a profile of interest in the area of angiogenesis [cord formation IC50 (�M) 2.1, 1.7, and 3.2].  These compounds formed the basis of a one-year collaborative agreement between Lilly and the University of Valencia, wherein a post-doctoral fellow was hired by the University to continue synthesizing new and diverse molecular entities designed by Lilly.  This was the first collaboration of Lilly with an academic institution in Europe that resulted from the OIDD program.  Using this unique model of partnering, Lilly and the University of Valencia integrated medicinal chemistry, computational chemistry, synthetic chemistry, and rapid parallel synthesis to produce a wide variety of new compounds based on the original molecular scaffold of interest. In this poster we provide details regarding the OIDD business model, and describe scientific and operational aspects of the collaboration between Lilly and the University of Valencia with an emphasis in the description of new synthetic methodologies.

Open innovation drug discovery: An example of symbiotic industry-academia collaboration

246th National Meeting (2013)

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