We prepared aliphatic polycarbonates with a simple ether functional group at the side chain by organocatalytic ring-opening polymerization of the corresponding cyclic monomers, yielding narrowly dispersed polymers. The number of platelets adhering on the polymer-coated substrates was almost identical to those on well-known antithrombotic polymers such as poly(2-methoxyethyl acrylate) and poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate). The hydration characteristics of the polycarbonates were evaluated by contact angle against water and thermal analysis of the hydrated polymers. The polymers were insoluble in water but showed decent hydrophilic surface properties, which may influence the platelet adhesion. The polycarbonates were found to be degraded by fairly slow enzymatic hydrolysis. Adhesion of other cell lines on the polymers was also assayed.

Antithrombotic biodegradable polycarbonates for regenerative medicines

246th National Meeting (2013)

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