A variety of polylatide-based polymer-drug conjugates were synthesized, characterized, and further studied for drug delivery applications. Acetylene-functionalized polylactides were prepared, and then their reactions with functionalized anticancer drug molecules afforded polylactide-based conjugates with hydrolysable linkages connecting drug moieties. Nanoparticles with high drug loadings can be readily prepared from the conjuagtes without water-soluble groups by nanoprecipitation. On the other hand, the conjugates with hydrophilic poly(ethylene oxide) grafts can directly serve as water-dispersible drug delivery systems. Sustained release of anticancer drugs was achieved in both cases. Their significant therapeutic effects were verified by biomedical assessment.

Biodegradable polymer-drug conjagates for sustained delivery of anticancer drugs

246th National Meeting (2013)

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