Polyethylene glycol (PEG) is widely used in medical and pharmaceutical applications for its biocompatibility, water-solubility, and chemically robust nature. Recently, there has been an increasing interest in functionalized PEG-based polymers and their applications, which are highly dependent on the nature of the functional groups. We report that propargyl substituted epoxides can be polymerized to give alkyne substituted PEGs. These polymers are synthons for post-polymerization modification by Cu-catalyzed, �click� reactions with organic azides. The results of the polymerizations and properties of the �click� modified polymers will be presented.

Synthesis and postpolymerization modification of "clickable" PEGs

246th National Meeting (2013)

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