Sulfoxaflor is the first insecticidal product from the new sulfoximine class of insect control agents. A broad-spectrum insecticide exhibiting excellent efficacy against many sap-feeding insect pests, including aphids, whiteflies, hoppers, and Lygus, sulfoxaflor is comparable in activity with other classes of insecticides targeting sap-feeding insects, including the neonicotinoids. Importantly, sulfoxaflor exhibits little to no cross-resistance in insects that are resistant to the neonicotinoids and other insecticides. A comprehensive effort was undertaken to understand better the SAR of this unique chemotype including the synthesis of analogs designed to probe the conformational requirements for the putative recognition elements. The design, synthesis, and biological evaluation of these targeted molecules will be discussed.

SAR studies of the new sulfoximine sap-feeding insecticide, sulfoxaflor

246th National Meeting (2013)

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