Choosing lead chemical classes for optimization is always difficult to determine. In the early 1980s, we chose leads from patents, and a few successful optimizations were achieved at Sumitomo Chemical in IGR and herbicide areas. Better efficacy was good enough to develop a compound, even if the mode of action (MOA) was the same as a competitor's compound. Now we are concerned with resistance in any area of agrochemicals. The mode of action is thought to be a more important factor in choosing the lead. Examples of successes and failures in choosing the lead will be discussed.

Did we select lead chemistries for optimization based on MOA or activity?

246th National Meeting (2013)

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