The successes of disease vector control have become increasingly threatened by the development of insecticide resistance.  Therefore, continued disease control efforts require the development of insecticides with novel modes of action.  Potassium channel-directed compounds have been screened in paralysis and lethality bioassays, as well as in electrophysiological assays, in the search for a selective and potent lead insecticide.  In larval bioassays, many of the known potassium channel blockers have LC50 values >100 ppm.  However, 4-aminopyridine, tetraethylammonium chloride, and 4-tert-octylcatechol have shown LC50 values that are <50 ppm.  Electrophysiological assays, including muscle depolarization and muscle twitch force recordings show responses consistent with potassium channel block and with paralytic effects.  Established and experimental blockers have also been tested on potassium channels of rat embryonic neurons, which generally show low sensitivity and suggest a favorable selectivity profile.

Evaluation of synthetic compounds as novel mosquitocides targeting potassium channels for control of<i> Aedes aegypti</i> and <i>Anopheles gambiae</i>

246th National Meeting (2013)

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Evaluation of synthetic compounds as novel mosquitocides targeting potassium channels for control of Aedes aegypti and Anopheles gambiae