Novel hydroxypropyl methylcellulose (HPMC) esters were evaluated for their performance in improving the aqueous solubility of crystalline hydrophobic drugs in spray-dried dispersions (SDDs). We prepared five HPMC esters from a single HMPC precursor with varying structure and substitution levels. SDDs with different matrices at 10 wt% loading of the model drug phenytoin had very similar bulk properties. In aqueous suspensions, the SDDs of several HPMC esters not only allowed for the attainment of  high initial supersaturation of phenytoin, but also maintained high concentrations for extended time. Such maintenance was ascribed to the inhibition of crystal nucleation. Structure�property relationships for these systems were developed and will be presented.

Enhancing the supersaturation of crystalline hydrophobic drugs with modified hydroxypropyl methyl cellulose

246th National Meeting (2013)

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