Hydroxypropylmethylcellulose acetate succinate (HPMCAS, Figure 1) has demonstrated utility in producing amorphous solid dispersions for active pharmaceutical compounds that are capable of enhancing free drug levels in solution, thereby leading to increased oral bioavailability of the compound?. Currently available hypromellose acetate succinate grades cover only a subspace of the potential design space, particularly with regard to the acetate and succinate substitution levels. Broader coverage of the compendial design space offers the ability to select polymers having properties optimized for drug release and sustainment of spray dried dispersions. In the present study, drug release rate and precipitation inhibition of spray dried dispersions for model compounds having a range of physicochemical properties were evaluated as a function of polymer properties such as the acetate and succinate substitution levels on the polymer. Optimal levels were found to be dependent on the properties of the model compound.

Impact of HPMCAS polymer properties on the in vitro performance of spray dried dispersions: A quality by design approach

246th National Meeting (2013)

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