Using the surface-specific vibrational spectroscopy, sum frequency generation (SFG), interactions between ozone and organic-coated mineral dust surfaces were monitored. Using an organosilane system which allows for molecular control of the orientation and steric accessibility of the carbon-carbon double bonds in surface-bound olefins, we measured the reaction rates of a wide range of terpenes and determined reactivity trends for immobilized chiral and achiral organic compounds.Counter-propagating second harmonic generation (SHG) was used to quantify the binding of selective estrogen receptor modulators (SERMs) to model cell membranes composed of planar-supported lipid bilayers. The effects of lipid phase and order, cholesterol content, and drug charge on binding were quantified. Comparisons of SERM binding in the presence and absence of the peripheral estrogen receptor, ERa, incorporated in the lipid bilayer were also made.

Using nonlinear optical spectroscopies to elucidate surface adsorption and reaction in systems ranging from atmospheric aerosols to drug-membrane interactions

246th National Meeting (2013)

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