Quorum sensing is the communication process used by bacteria to control collective behaviors including bioluminescence, biofilm production, and virulence. Targeting virulence, by inhibiting quorum sensing, could constitute a new leading edge strategy to combat Gram-negative bacteria, which is of increasing importance with the rise of antibiotic resistant strains. A library of small molecules was synthesized and the compounds were investigated for their ability to block virulence in Pseudomonas aeruginosa by disrupting the LuxIR quorum sensing circuits, leading to the identification of new potent inhibitors.

Blocking virulence: Disruption of quorum sensing in Pseudomonas aeruginosa

246th National Meeting (2013)

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