The intermediate involved in the reversible self-assembly associated with an initial stage of fibrillogenesis (i.e., a hallmark onset process of Alzheimer's disease) was stably prepared by placing the amyloid beta peptide 1-42 (A�1-42) over the nanoscale gold colloid in dimethyl sulfoxide. The degree of repetition of a reversible self-assembly process heavily depended on the temperature as well as the size of gold nanoparticles. It implied that a unit structure of an intermediate was significantly affected by the surface potential and a thermal energy.

Temperature dependent formation of pre-fibrillar intermediates in Alzheimer's disease

246th National Meeting (2013)

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