High-speed ball milling (HSBM) is a form of mechano-chemistry used to minimize waste through mechanical energy under solvent free conditions. In an effort to expand our understanding of mechano-chemistry, we performed the Schmidt reaction under ball milling conditions. Traditionally, the Schmidt reaction uses a alkyl azide and an aldehyde to give a secondary amide using a strong acid. We were able to conduct this reaction under more environmentally benign conditions through the omission of solvent and strong acid. We expanded to ketones and other electrophilic substrates.

Schmidt reaction under high speed ball milling

246th National Meeting (2013)

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