Gold catalysis has grown rapidly in the past ten years as an effective methodology for carbon-carbon bond forming reactions, among others. With the generation of new stereocenters makes enantioselectivity a desirable goal for Gold catalysis. Currently, N-heterocyclic carbenes (NHCs) provide certain advantages such as thermal and atmospheric stability and reduced toxicity compared to phosphine-based ligand systems. Unfortunately, there are few reports of chiral, enantioselective NHC catalysts compared to those of phosphines. We are reporting the synthesis and structural characterization of a novel series of chiral, bulky NHC-gold catalysts . The activity of the catalysts for [3+2] cycloadditions and [4+2] annulations to tetracyclic indole derivatives is also reported.

Synthesis and characterization of novel chiral NHC-Gold (I) complexes

246th National Meeting (2013)

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