A general protocol for the synthesis of ferrocene based thiourea and its derivatives have been reported in this presentation. Single crystal X-ray diffraction analysis and multi-nuclear NMR spectroscopy (1H & 13C) have been used to establish their identities in the solid state and also in solution. DNA binding studies based on UV-vis spectrophotometric titration shows the potential of these organometallic compounds as an anti-tumor drug. Membrane penetration studies have been carried out for some compounds with model lipid membrane interfaces prepared from CTAB, TTAB and SDS surfactants using 1H NMR and UV-Vis spectroscopic techniques. Results show the presence of these molecules in the interfacial regions of the self assembled systems.

Ferrocene based thiourea and its analog as potential anticancer agents: Synthesis, characterization, DNA binding, and model lipid membrane interaction study

246th National Meeting (2013)

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