Because of versatile DNA binding and possible applications in photodynamic, anticancer, and antiviral therapies, there is a considerable interest in water soluble cationic porphyrins. Different methods can be used to characterize DNA binding motifs such as absorption, emission, and circular dichroism spectroscopies, as well as viscometry. In case of classic H2T4 porphyrin, or 5,10,15,20-tetra(N-methylpyridinium-4-yl)porphyrin, the mode of binding depends on the base composition of the DNA hosts. The porphyrin binds adenine-thymine rich sequences externally whereas intercalation occurs in guanine-cytosine rich sequences. Our studies of the copper derivative of the flexible alkyl-substituted tetra-cationic porphyrin,[Cu(TC3MI)] or 5,10,15,20-tetra[(3-(3'-methylimidazolium-1'-yl)propyl])porphyrinato copper(ll), binds by intercalation independent of the sequence. An aggregated form of the porphyrin appears at high loading.

Synthesis and DNA-binding studies of a cationic tetra-alkyl substituted porphyrin

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.