We are studying the reaction of analogs of the anticancer drug cisplatin with amino acids that differ in size and shape. The reaction of cisplatin with proteins likely precedes reaction with DNA in the body and the size and shape of the platinum complexes often affects the rate of reaction with proteins. In this study, platinum(II) nitrate complexes are reacted with the amino acids cysteine, methionine, and histidine simutaneously. These reactions are monitored by proton NMR spectroscopy.  Preliminary testing suggests that the bulkier ligand reacts faster with the cysteine than the other amino acids when reacted simultaneously. The reactions of cysteine with the cisplatin analogs previously conducted show that the bulk of the ligand significantly slows down the reaction. When in the competition reaction, it is shown that the bulkier complex reacts more with acetylcysteine than with methionine or histidine.

Reaction rates of cysteine, methionine, and histidine with analogs of cisplatin

246th National Meeting (2013)

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