Understanding and modulating carriers' cellular interactions and subsequent entries are pivotal to achieve high delivery and labeling efficiency. Using self-assembly of positively charged, non-aqueous soluble semiconducting conjugated polymers (CPs) in water, we have demonstrated that live cell imaging and small interfering RNA delivery to cells to knockdown a target gene. In this presentation, side chain-dependent cellular entries and cancer cell-specific labeling of conjugated polymer nanoparticles (CPNs) will be discussed. CPNs are emerging biomaterials exhibiting excellent photophysical and tunable biophysical properties for biological and biomedical sensing, labeling, and delivery.

Conjugated polymer nanoparticles for cellular delivery and imaging applications

246th National Meeting (2013)

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