The inorganic and coordination chemistry of iron dictates the processes whereby this biologically essential element is moved across membranes and through compartments. These same inorganic chemistry characteristics (redox, Lewis acidity) are central to how life has evolved to require iron as an essential nutrient for virtually every living cell. We will describe how the propensity of iron toward redox and hydrolysis in neutral aqueous medium results in low aqueous solubility and the generation of toxic free radicals including reactive oxygen species (ROS), which must be managed through coordination chemistry. This talk will highlight the evolution of a research program which focuses on the selective mobility of specific metal ions in industrial, environmental, and biological processes. Our approach progresses from studies of small molecule specific metal chelators and their selective compartmentalization by molecular recognition and transport through artificial bulk liquid (BLM) and polymer film membranes with theoretical, environmental cleanup, and precious metal recovery applications, to studies of protein mediated cellular iron acquisition through endocytosis in red blood cells (RBC) and the hijacking of this essential nutrient by pathogenic gram negative bacteria. The influence and importance of the ACS, collaborations, and leadership positions on the progression of this scientific adventure will be presented.

Moving iron across membranes and through compartments in biology

246th National Meeting (2013)

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