The evolution of the process to prepare CEP-32215, a Histamine H3 receptor antagonist, will be presented. Two routes detailing preparation of supplies for biological screening will be discussed along with the final optimized process used to manufacture preclinical supplies. Details regarding a novel Suzuki coupling approach used in the scale-up campaign will be presented.

Synthesis of CEP-32215: Development and scale-up of an optimized route using a Suzuki coupling

246th National Meeting (2013)

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